The aging process is a significant contributor to the development of cardiovascular diseases due to the buildup of waste materials, such as damaged mitochondria, and a decline in stress response mechanisms. This leads to an increase in oxidative stress over time. According to the free radical theory of aging, elevated levels of reactive oxygen species (ROS) cause DNA damage in the mitochondria and genome, which leads to sustained oxidative stress and contributes to tissue dysfunction and aging. Within the cardiovascular system, ROS are produced by NADPH oxidases as a part of normal function