Contact inhibition is the property of normal cell while in cancer cell they lost it and cell growth occurs uncontrollably and proliferate to other portions of body but if this process of contact inhibition can be reactivated in cancer cell they start to being controlled and after some time become the normal cell this article consist of some dependency factor which can results in reactivation of contact inhibition.The process in which normal cells stop dividing after being in touch with each other is termed as contact inhibition. During cancer this process of contact inhibition is not performed by the cells which results in unwanted growth.. So if a cell can maintain this contact inhibition again then uncontrolled division of cells (i.e. cancer) can be treated. For the contact inhibition majorly a trans membrane protein cadherin selectively epithelial cadherin is responsible. In cancer cells this E-cadherin loss results in the uncontrolled growth and loss of contact inhibition