Probiotics are characterized as “live microorganisms'' when regulated insufficient sums, present a medical advantage on the host”. The use of probiotics has shown promising effects on the prevention and treatment of different inflammatory skin disorders such as acne and atopic dermatitis. Although probiotic bacteria have documented skin benefits, live cultures are generally not preferred in cosmetics. Rather than including live bacteria cultures, many of the probiotic skincare formulae use bacteria fragments or metabolites. There is not currently any science developed to support the idea that live cells are any more effective when applied to the skin than these fragments. In the near future, some brands using live bacteria might emerge. We will briefly review the science supporting the use of topical probiotics in dermatological therapy skincare products.