Numerous factors regulate mood changes of pregnancy; such as physiological/biological shifts related stress, changes in metabolism, or shifting levels of estrogen, progesterone and Oxytocin hormones. Ovarian hormones prepare the mother’s body for successful fertilization while placental hormones promote maternal adaptations to ensure optimum fetal growth and sustain pregnancy; Changes in hormone levels can significantly affect production of mood-regulating neurotransmitters. Each woman responds to these changes differently. Some experience heightened emotions, while others feel depressed or anxious. It has been generally observed that moodiness flares around 6-10 weeks of pregnancy, eases during second trimester, and reappears as the ‘due date’ approaches.