Genetics and Apicomplexan-Related Parasitic Diseases

Picomplexa (also known as Apicomplexia) are a large phylum of parasitic organisms. They are mostly unicellular and spore-forming in nature. Apicomplexa are parasites of humans and terrestrial animals and have been implicated in parasitic diseases of marine animals. Some parasitic diseases of economic importance caused by Apicomplexa include Babesiosis, Cryptosporidiosis, Cystoisosporiasis, Malaria, and Toxoplasmosis.

Diseases caused by Apicomplexa are responsible for the deaths of millions of humans, livestock, and wild animals. The economic losses from these diseases annually on a global scale are quite astronomical. While great efforts in epidemiology, vector control, and used of medicinal drugs have been very helpful in bringing reduced incidence around the world and there are a great deal of advancements toward the eradication of Apicomplexa-based disease, elimination is far from being in sight, especially with the current rise of drug-resistance in these organisms. Controlling, preventing, and eliminating apicomplexans is dependent on a better understanding of their genetics, mechanisms of infection, and immunity control methods (such as drugs/vaccines and vector control methods).

Apicomplexa infect humans, livestock, wild and domesticated animals, birds, and aquatic organisms. The mode of infection in most cases is well-defined, but knowledge of the genetics of infection, host-parasite interaction, vector control, and candidate vaccines have been challenging and require in-depth study to facilitate improvement in management towards elimination..

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