Introduction: Phenobarbital is utilized in the treatment of a wide range of seizures, except for nonattendance seizures. It is no less powerful at seizure control than phenytoin, anyway phenobarbital isn't also endured. Phenobarbital may give a clinical favorable position over carbamazepine for rewarding fractional beginning seizures. Carbamazepine may give a clinical bit of leeway over phenobarbital for summed up beginning tonicclonic seizures. It’s extremely long dynamic half-life (53–118 hours) implies for certain individual’s dosages don't need to be taken each day, especially once the portion has been settled over a time of a little while or months, and seizures are adequately controlled. The main line drugs for treatment of status epilepticus are benzodiazepines, for example, lorazepam or diazepam. In the event that these fizzles, at that point phenytoin might be utilized, with phenobarbital being an option in the US, yet utilized just third line in the UK. Bombing that, the main treatment is sedation in escalated care. The World Health Organization (WHO) gives phenobarbital a first-line suggestion in the creating scene and it is usually utilized there. Phenobarbital is the main line decision for the treatment of neonatal seizures. Worries that neonatal seizures in themselves could be destructive make most doctors treat them forcefully. No solid proof, however, underpins this methodology. Phenobarbital is here and there utilized for liquor detoxification and benzodiazepine detoxification for its calming and hostile to convulsant properties. The benzodiazepines chlordiazepoxide (Librium) and oxazepam (Serax) have generally substituted phenobarbital for detoxification. Levetiracetam, showcased under the exchange name Keppra among others, is a prescription used to treat epilepsy. It is utilized for incomplete beginning, myoclonic, or tonic-clonic seizures. It is taken by mouth as a quick or broadened discharge plan or by infusion into a vein. Levetiracetam is utilized in mix with different drugs to treat specific kinds of seizures in grown-ups and kids with epilepsy. Levetiracetam is in a class of prescriptions called anticonvulsants.