As one of the most complex physiological states, pregnancy has a long-lasting impact on the future maternal and child health. Although most pregnancies will follow a regular course, certain complications may occur. Among them, gestational diabetes mellitus and hypertension remain the most frequent. Besides the increased risk of adverse outcomes during pregnancy and delivery, gestational diabetes and other metabolic complications during pregnancy also increase the mothers’ risk of type 2 diabetes mellitus and cardiovascular disease in later life. In addition, their offspring are more likely to develop endocrine disorders associated with elevated cardiovascular disease risk, such as obesity. The etiology and pathogenesis of pregnancy complications are not completely understood and, despite efforts to improve prenatal and perinatal health care, we are still facing a lack of adequate cardiometabolic prevention. This Research Topic aims to explore the risk factors and to improve understanding of the mechanisms behind the development of pregnancy complications, such as gestational diabetes, but also hypertension, preeclampsia and intrauterine growth restriction, and to discover how these factors relate to long-term consequences regarding the future cardiometabolic health of the mother and the offspring.This Research Topic aims to increase awareness on the long-lasting cardiometabolic consequences of high-risk pregnancies by reaching out to the scientific community and health care professionals. Prospective studies that evaluate changes of cardiometabolic risk factors across the lifespan and/or that offer new perspectives for preventive and therapeutic measures are also welcomed.