Regarding diabetes-related carcinogenesis and androgen deprivation therapy-related metabolic disease, respectively, prostate cancer and ADT are linked to diabetes. This study's objective is to thoroughly review the pertinent literature. In the US, it is projected that 218,000 men receive a new prostate cancer diagnosis each year. 10% of them are still discovered to have metastases, while 30% of patients with nonmetastatic prostate cancer had recently undergone ADT in addition to them. Contrary to other cancers, type 2 diabetes has been linked to a decreased incidence of prostate cancer, according to population-based studies. However, more recent large cohort studies have found a link between diabetes and advanced, high-grade prostate cancer.