Journal of Thyroid Disorders & Therapy offers the most comprehensive and reliable information pertaining to the latest developments in the field. The Journal also believes in advancing new hypotheses and opinions by means of its high-quality Reviews, Perspectives, and Commentaries. Thus, the content published in the journal is original and comprehensive.

Radioactive iodine therapy (RAIT) is a useful option in the treatment of Graves’ disease; other treatment options include antithyroid drugs (ATDs) and surgery. Endocrinologists select appropriate therapies based on clinical characteristics such as age, thyroid volume, complications, and whether the patient is planning to become pregnant. RAIT does not require hospitalization and can reliably correct hyperthyroidism; however, changes in thyrotropin receptor antibody (TRAb) and thyroid stimulating antibody (TSAb) levels significantly influence the course of pregnancy and the development or exacerbation of Graves' ophthalmopathy.

In a study by Laurberg et al. patients with Graves' disease were randomly assigned to ATD treatment, thyroidectomy, or RAIT group, and their clinical courses were reviewed prospectively. In the ATD and thyroidectomy groups, TRAb levels decreased gradually after treatment, and 70-80% of patients were observed to be TRAb- negative at 18 months; however, in the RAIT group, TRAb levels increased after treatment, reached a maximum at three months, and then decreased gradually to pre-treatment levels one year post-treatment. Laurberg et al. found that there were fewer TRAb- negative patients in the RAIT group than in the other groups. In a retrospective study by Atkinson et al. 19 patients with Graves' disease treated by RAIT had TSAb- and TRAb-positivity rates of 84% and 68%, respectively, before RAIT, but the positivity rates for both the antibodies had increased to 100% three months later. The TSAb-positivity rate decreased to 42% one to two years after RAIT; however, the TRAb-positivity rate remained high at 68%. Therefore, it is thought that the levels of TRAb and TSAb after RAIT increase and do not readily decrease. However, we found that not all Graves’ patients had increased TSAb levels, and some had decreased TSAb levels after RAIT.

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Denise Williams
Editorial Manager     
Journal of Thyroid Disorders & Therapy
E-mail id: thyroiddisorders@longdomjournal.org