Diabetes mellitus is a challenging disease; its health damage on human population is increasing globally. The need for remedy of diabetes is progressively pursued by professionals. The adverse effect of synthetic drugs such as metformin and glibenclamide are becoming a source of concern. This paves way for herbal therapy with no or minimal site effect to control and treat diabetes mellitus. This research evaluates the effect of Irvingia gabonesis seeds extract on some lipid profile indices of wistar albino rats. Glibenclamide was used as a control standard drug. A 200 mg/kg of alloxan was used to induce diabetes on rats after fasting. The median lethal dose was ascertained at 5000 mg/kg of the extract, with no indication of toxicity. Upon induction of alloxan, fasting blood glucose was significantly (p<0.05) high, which indicates defectiveness of insulin or damage pancreatic beta cells read more..